Article
A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.
The Journal of biological chemistry - 20 Dec 2013
Okatsu Kei, Uno Midori, Koyano Fumika, Go Etsu, Kimura Mayumi, Oka Toshihiko, Tanaka Keiji, Matsuda Noriyuki
Abstract excerpt
Parkinsonism typified by sporadic Parkinson disease is a prevalent neurodegenerative disease. Mutations in PINK1 (PTEN-induced putative kinase 1), a mitochondrial Ser/Thr protein kinase, or PARKIN, a ubiquitin-protein ligase, cause familial parkinsonism. The accumulation and autophosphorylation of PINK1 on damaged mitochondria results in the recruitment of Parkin, which ultimately triggers quarantine and/or...
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