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Article

hCTR1: a human gene for copper uptake identified by complementation in yeast.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 1997

Zhou B, Gitschier J

Abstract excerpt

The molecular mechanisms responsible for the cellular uptake of copper in mammalian cells are unknown. We describe isolation of a human gene involved in this process by complementation of the yeast high-affinity copper uptake mutant, ctr1. Besides complementing ctr1 growth defect on nonfermentable media, the human gene also rescues iron transport and SOD1 defects in ctr1 yeast. Overexpression of the gene in yeast...

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Identifiers

PMID: 9207117
DOI: 10.1073/pnas.94.14.7481
PMCID: PMC23847

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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