Article
Divergent frequencies of IGF-I receptor-expressing blood lymphocytes in monozygotic twin pairs discordant for Graves' disease: evidence for a phenotypic signature ascribable to nongenetic factors.
The Journal of clinical endocrinology and metabolism - 1 May 2009
Douglas Raymond S, Brix Thomas H, Hwang Catherine J, Hegedüs Laszlo, Smith Terry J
Abstract excerpt
CONTEXT: Graves' disease (GD) is an autoimmune process of the thyroid and orbital connective tissues. The fraction of T and B cells expressing IGF-I receptor (IGF-IR) is increased in GD. It is a potentially important autoantigen in GD. Susceptibility to GD arises from both genetic and acquired factors. OBJECTIVE: The aim of the study was to determine whether the increased frequency of IGF-IR-expressing T and B...
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