Article

The role of four cholesterol-recognition motifs localized between amino acid residues 400-550 in regulating translocation and lytic activity of Adenylate Cyclase Toxin

2021-11-26

Abstract excerpt

<h4>ABSTRACT</h4> Adenylate Cyclase Toxin (ACT or CyaA) is an important virulence factor secreted by Bordetella pertussis , the bacterium causative of whooping cough, playing an essential role in the establishment of infection in the respiratory tract. ACT is a pore-forming cytolysin belonging to the RTX (Repeats in ToXin) family of leukotoxins, capable of permeabilizing several cell types and pure lipid vesicle...

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Literature Corpus work: 27a29451-3886-5158-8ef8-9c9c8d26ff4c
DOI: 10.1101/2021.11.26.470122

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