Article
EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2009
Inamura Kentaro, Takeuchi Kengo, Togashi Yuki, Hatano Satoko, Ninomiya Hironori, Motoi Noriko, Mun Ming-yon, Sakao Yukinori, Okumura Sakae, Nakagawa Ken, Soda Manabu, Choi Young Lim, Mano Hiroyuki, Ishikawa Yuichi
Abstract excerpt
A subset of lung cancers harbors a small inversion within chromosome 2p, giving rise to a transforming fusion gene, EML4-ALK (echinoderm microtubule-associated protein-like 4 gene and the anaplastic lymphoma kinase gene), which encodes an activated tyrosine kinase. We have earlier examined the presence of EML4-ALK by multiplex reverse transcription-polymerase chain reaction in 363 specimens of lung cancer,...
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