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Article

An extremely rare case of small-cell lung cancer harboring variant 2 of the EML4-ALK fusion gene.

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2013

Toyokawa Gouji, Takenoyama Mitsuhiro, Taguchi Kenichi, Toyozawa Ryo, Inamasu Eiko, Kojo Miyako, Shiraishi Yoshimasa, Morodomi Yosuke, Takenaka Tomoyoshi, Hirai Fumihiko, Yamaguchi Masafumi, Seto Takashi, Shimokawa Mototsugu, Ichinose Yukito

Abstract excerpt

Anaplastic lymphoma kinase (ALK) fuses echinoderm microtubule-associated protein-like 4 (EML4) to acquire a transforming activity in lung adenocarcinomas. However, the presence of an EML4-ALK fusion gene in other lung cancer histologies is an extremely rare phenomenon. A 43-year-old female was referred to our department due to dyspnea on effort and left back pain. Computed tomography (CT) showed a large mass in...

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Source

Identifiers

PMID: 23787064
DOI: 10.1016/j.lungcan.2013.05.022

Genes

ALK
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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