Article
Steroids do not prevent photoreceptor degeneration in the light-exposed T4R rhodopsin mutant dog retina irrespective of AP-1 inhibition.
Investigative ophthalmology & visual science - 1 Jul 2009
Gu Danian, Beltran William A, Pearce-Kelling Sue, Li Zexiao, Acland Gregory M, Aguirre Gustavo D
Abstract excerpt
PURPOSE: AP-1 has been proposed as a key intermediate linking exposure to light and photoreceptor cell death in rodent light-damage models. Inhibition of AP-1 associated with steroid administration also prevents light damage. In this study the role of steroids in inhibiting AP-1 activation and/or in preventing photoreceptor degeneration was examined in the rhodopsin mutant dog model. METHODS: The dogs were dark...
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