Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional and structural recovery of the retina after gene therapy in the RPE65 null mutation dog.

Investigative ophthalmology & visual science - 1 Apr 2003

Narfström Kristina, Katz Martin L, Bragadottir Ragnheidur, Seeliger Mathias, Boulanger Ana, Redmond T Michael, Caro Lynette, Lai Chooi-May, Rakoczy P Elizabeth

Abstract excerpt

PURPOSE: To assess the efficacy of AAV-mediated gene therapy to restore vision in a large number of RPE65(-/-) dogs and to determine whether systemic and local side effects are caused by the treatment. METHODS: Normal RPE65 dog cDNA was subcloned into an rAAV vector under control of a cytomegalovirus promoter, and an AAV.GFP control vector was also produced with the titers 2 x 10(12) particles/mL and 2 x 10(10)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dark Adaptation
Share to Dependovirus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Indicators and Reagents

Share to Night Blindness

Share to Pigment Epithelium of Eye

Share to Retinal Degeneration

Share to Uveitis

Source

Identifiers

PMID: 12657607
DOI: 10.1167/iovs.02-0595

Genes

RPE65
RPE
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional and structural recovery of the retina after gene therapy in the RPE65 null mutation dog.PMID 12657607Read ↗

Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness.Semantic proximity Read ↗

Successful Gene Therapy in Older Rpe65-Deficient Dogs Following Subretinal Injection of an Adeno-Associated Vector Expressing <i>RPE65</i>Semantic proximity Read ↗

Assessment of structure and function over a 3-year period after gene transfer in RPE65-/- dogs.Semantic proximity Read ↗

Gene therapy in the second eye of RPE65-deficient dogs improves retinal functionSemantic proximity Read ↗

Morphological aspects related to long-term functional improvement of the retina in the 4 years following rAAV-mediated gene transfer in the RPE65 null mutation dog.Semantic proximity Read ↗

Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epitheliumSemantic proximity Read ↗

Long-term effect of gene therapy on Leber's congenital amaurosis.Semantic proximity Read ↗

[RPE65-associated retinal dystrophies: gene therapy preserves vision].Semantic proximity Read ↗

Gene Therapy in a Large Animal Model of PDE6A-Retinitis PigmentosaSemantic proximity Read ↗

RPE65 gene therapy slows cone loss in Rpe65-deficient dogsSemantic proximity Read ↗

Leber congenital amaurosis due to RPE65 mutations and its treatment with gene therapy.Semantic proximity Read ↗

Effect of gene therapy on visual function in Leber's congenital amaurosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.