Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms.

Gastroenterology - 1 Aug 2007

Pilotto Alberto, Seripa Davide, Franceschi Marilisa, Scarcelli Carlo, Colaizzo Donatella, Grandone Elvira, Niro Valeria, Andriulli Angelo, Leandro Gioacchino, Di Mario Francesco, Dallapiccola Bruno

Abstract excerpt

BACKGROUND AND AIMS: Several nonsteroidal anti-inflammatory drugs (NSAIDs) are metabolized by the cytochrome P450 2C9 (CYP2C9). Two common variants of the CYP2C9 gene (CYP2C9*2 and *3) were reported to significantly affect the activity of the CYP2C9 enzyme. The aim of this study was to evaluate the impact of CYP2C9 polymorphisms on the risk of gastroduodenal bleeding in acute NSAID users. METHODS: This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C9

Share to Odds Ratio

Share to Peptic Ulcer

Share to Pyrazoles

Share to Risk Assessment

Share to Sulfonamides

Source

Identifiers

PMID: 17681167
DOI: 10.1053/j.gastro.2007.05.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms.PMID 17681167Read ↗

Interaction of CYP2C8 and CYP2C9 genotypes modifies the risk for nonsteroidal anti-inflammatory drugs-related acute gastrointestinal bleeding.Semantic proximity Read ↗

Genetic predisposition to acute gastrointestinal bleeding after NSAIDs use.Semantic proximity Read ↗

Allele variants of the cytochrome P450 2C9 genotype in white subjects from The Netherlands with serious gastroduodenal ulcers attributable to the use of NSAIDs.Semantic proximity Read ↗

An update on the pharmacogenomics of NSAID metabolism and the risk of gastrointestinal bleeding.Semantic proximity Read ↗

CYP2C9 variants as a risk modifier of NSAID-related gastrointestinal bleedingSemantic proximity Read ↗

Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine?Semantic proximity Read ↗

Is cytochrome P450 2C9 genotype associated with NSAID gastric ulceration?Semantic proximity Read ↗

[Clinical pharmacogenomics for CYP2C8 and CYP2C9: general concepts and application to the use of NSAIDs].Semantic proximity Read ↗

CYP2C9 polymorphism in non-steroidal anti-inflammatory drugs-induced gastropathy.Semantic proximity Read ↗

The role of CYP2C9*2, CYP2C9*3 and VKORC1-1639 variants on the susceptibility of upper gastrointestinal bleeding: A full case-control study.Semantic proximity Read ↗

Clinical and pharmacogenetic features of patients with upper gastrointestinal lesions at a multidisciplinary hospital: the role of nonsteroidal anti-inflammatory drugs.Semantic proximity Read ↗

Novel Use of Pharmacogenetic Testing in the Identification of CYP2C9 Polymorphisms Related to NSAID-Induced Gastropathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.