Article
Acute infection with a single hepatitis C virus strain in dialysis patients: Analysis of adaptive immune response and viral variability.
Journal of hepatology - 1 Apr 2009
Weseslindtner Lukas, Neumann-Haefelin Christoph, Viazov Sergei, Haberstroh Anita, Kletzmayr Josef, Aberle Judith H, Timm Joerg, Ross Stefan R, Klauser-Braun Renate, Baumert Thomas F, Roggendorf Michael, Thimme Robert, Holzmann Heidemarie
Abstract excerpt
BACKGROUND/AIMS: While the adaptive immune response is crucial for spontaneous resolution of acute hepatitis C virus (HCV) infection, it also constitutes the driving force for viral escape. For acutely HCV-infected dialysis patients, little is known about the host response and its impact on viral evolution. METHODS: Four haemodialysis patients accidentally infected with the same HCV strain were prospectively...
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