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Article

Ploidy Reductions in Murine Fusion-Derived Hepatocytes

19 Feb 2009

Abstract excerpt

We previously showed that fusion between hepatocytes lacking a crucial liver enzyme, fumarylacetoacetate hydrolase (FAH), and wild-type blood cells resulted in hepatocyte reprogramming. FAH expression was restored in hybrid hepatocytes and, upon in vivo expansion, ameliorated the effects of FAH deficiency. Here, we show that fusion-derived polyploid hepatocytes can undergo ploidy reductions to generate daughter...

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PMID: 19229314
DOI: 10.1371/journal.pgen.1000385

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