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Article

Cell fusion is the principal source of bone-marrow-derived hepatocytes.

Nature - 24 Apr 2003

Wang Xin, Willenbring Holger, Akkari Yassmine, Torimaru Yumi, Foster Mark, Al-Dhalimy Muhsen, Lagasse Eric, Finegold Milton, Olson Susan, Grompe Markus

Abstract excerpt

Evidence suggests that haematopoietic stem cells might have unexpected developmental plasticity, highlighting therapeutic potential. For example, bone-marrow-derived hepatocytes can repopulate the liver of mice with fumarylacetoacetate hydrolase deficiency and correct their liver disease. To determine the underlying mechanism in this murine model, we performed serial transplantation of bone-marrow-derived...

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Identifiers

PMID: 12665832
DOI: 10.1038/nature01531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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