Article
Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.
Circulation journal : official journal of the Japanese Circulation Society - 1 Apr 2009
Kamide Kei, Yang Jin, Matayoshi Tetsutaro, Takiuchi Shin, Horio Takeshi, Yoshii Masayoshi, Miwa Yoshikazu, Yasuda Hisayo, Yoshihara Fumiki, Nakamura Satoko, Nakahama Hajime, Miyata Toshiyuki, Kawano Yuhei
Abstract excerpt
BACKGROUND: The response of blood pressure (BP) to L-type dihydropyridine calcium-channel blockers (dCCBs) differs among individuals. METHODS AND RESULTS: A pharmacogenomic analysis was undertaken in 161 patients with essential hypertension who were treated with dCCBs to study whether genetic polymorphisms of the calcium channel alpha1C and alpha1D subunit genes, CACNA1C and CACNA1D, are associated with the...
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