Article
Association study between polymorphisms in the CACNA1A, CACNA1C, and CACNA1H genes and drug-resistant epilepsy in the Chinese Han population.
Seizure - 1 Aug 2015
Lv Nan, Qu Jian, Long Hongyu, Zhou Luo, Cao Yuze, Long Lili, Liu Zhaoqian, Xiao Bo
Abstract excerpt
PURPOSE: As important ion channels of the central nervous system, calcium channels not only take part in epileptogenesis but also act as the targets of commonly used antiepileptic drugs (AEDs). Thus, this study aimed to provide the first investigation of the association between CACNA1A, CACNA1C, and CACNA1H single nucleotide polymorphisms (SNPs) and AED resistance in the Chinese Han population. METHODS: We...
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