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Article

[Impact of CACNA1C polymorphisms on antihypertensive efficacy of calcium channel blocker].

Zhonghua xin xue guan bing za zhi - 1 Jan 2012

Sun Qian, Li Qing-xian, Song Xi-fa, Zheng Song-gui, Yan Feng, Chen Peng, Tang Ji-fei, Niu Yu-xin, Bao Qi-yu, Zhang Guo-qiang, Hu Yun-liang

Abstract excerpt

OBJECTIVE: To explore the relationship between genetic polymorphisms of CACNA1C that encoded the a1c subunit of the L-type calcium channel and the efficacy of calcium channel blocker (CCB, Nifedipine extended release tablet/20 mg/d) in essential hypertension (EH) patients of Han Chinese in Wenzhou. METHODS: For the enrolled 103 EH patients, Multiplex Polymerase Chain Reaction (Multi-PCR) and matrix assisted laser...

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PMID: 22490625

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