Article
Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in the Czech Republic.
Human mutation - 1 Apr 2009
Polakova V, Pardini B, Naccarati A, Landi S, Slyskova J, Novotny J, Vodickova L, Bermejo J L, Hanova M, Smerhovsky Z, Tulupova E, Kumar R, Hemminki K, Vodicka P
Abstract excerpt
The Czech Republic has one of the highest incidences of colorectal cancer (CRC) in the world. To assess the role of genetic variants on the disease, we genotyped polymorphisms in the TP53 (rs17878362:A(1)>A(2), rs1042522:G>C, rs12947788:C>T, and rs17884306:G>A), CDKN1A (rs1801270:C>A and :C>T), and CDKN2A (:G>A, :C>G, and :C>T) genes in 614 hospital-based CRC cases and 614...