Article
An in vivo genome wide gene expression study of circulating monocytes suggested GBP1, STAT1 and CXCL10 as novel risk genes for the differentiation of peak bone mass.
Bone - 1 May 2009
Lei Shu-Feng, Wu Shan, Li Li-Ming, Deng Fei-Yan, Xiao Su-Mei, Jiang Cheng, Chen Yuan, Jiang Hui, Yang Fang, Tan Li-Jun, Sun Xiao, Zhu Xue-Zhen, Liu Man-Yuan, Liu Yao-Zhong, Chen Xiang-Ding, Deng Hong-Wen
Abstract excerpt
Peak bone mass (PBM) is an important determinant of osteoporosis. Circulating monocytes serve as early progenitors of osteoclasts and produce important molecules for bone metabolism. To search for genes functionally important for PBM variation, we performed a whole genome gene differential expression study of circulating monocytes in human premenopausal subjects with extremely low (N=12) vs. high (N=14) PBM. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.