In Vivo Genome-Wide Expression Study on Human Circulating B Cells Suggests a Novel<i>ESR1</i>and<i>MAPK3</i>Network for Postmenopausal Osteoporosis

Abstract excerpt

INTRODUCTION: Osteoporosis is characterized by low BMD. Studies have shown that B cells may participate in osteoclastogenesis through expression of osteoclast-related factors, such as RANKL, transforming growth factor beta (TGFB), and osteoprotegerin (OPG). However, the in vivo significance of B cells in human bone metabolism and osteoporosis is still largely unknown, particularly at the systematic gene...

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