Article
The human skeletal alpha-actin gene is regulated by a muscle-specific enhancer that binds three nuclear factors.
Gene expression - 1 Jan 1992
Muscat G E, Perry S, Prentice H, Kedes L
Abstract excerpt
The tissue-specific distal promoter of the human skeletal alpha-actin gene (-1282 to -708) induces transcription in myogenic cells approximately 10-fold and, with the most proximal promoter domain (-153 to -87), it synergistically increases transcription 100-fold (Muscat and Kedes 1987). We report here that it is a short fragment of the distal promoter, the distal regulatory element (DRE) from -1282 to -1177 that...
Topics
- Actins
- Animals
- Base Sequence
- Cells, Cultured
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Humans
- Mice
- Molecular Sequence Data
- Muscles