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Article

Highly sensitive determination of microRNA using target-primed and branched rolling-circle amplification.

Angewandte Chemie (International ed. in English) - 1 Jan 2009

Cheng Yongqiang, Zhang Xian, Li Zhengping, Jiao Xiaoxia, Wang Yucong, Zhang Yali

Abstract excerpt

One-nucleotide differences in microRNAs (miRNAs) can be discriminated in an assay based on a branched rolling-circle amplification (BRCA) reaction and fluorescence quantification. With the proposed method miRNA can be detected at concentrations as low as 10 fM, and the miRNA in a total RNA sample...

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PMID: 19219883
DOI: 10.1002/anie.200805665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19219883-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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