Article
Expression of TLR-4 and -2 in peripheral mononuclear cells in renal transplant patients with TLR-4 gene polymorphism.
International immunopharmacology - 1 Dec 2010
Nogueira Eliana, Salomao Reinaldo, Brunialti Milena Karina Colló, Ozaki Kikumi S, Marques Geórgia D M, Cenedeze Marcos A, Câmara Niels Olsen Saraiva, Pacheco-Silva Alvaro
Abstract excerpt
INTRODUCTION: TLR-4 has also been identified as a receptor for endogenous alarmins, which are increased post transplantation. TLR-4 has also been associated with a polymorphism that could impact graft outcome. OBJECTIVE: To assess the expression of TLR-4 in kidney transplant patients carrying or not a polymorphism. METHODS: TLR-4 polymorphism (A299G/T399I) was studied in 200 renal transplant patients. Healthy...
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