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Article

Changes in negative charge at the luminal mouth of the pore alter ion handling and gating in the cardiac ryanodine-receptor.

Biophysical journal - 18 Feb 2009

Mead-Savery Fiona C, Wang Ruiwu, Tanna-Topan Bhavna, Chen S R Wayne, Welch William, Williams Alan J

Abstract excerpt

We have tested the hypothesis that a high density of negative charge at the luminal mouth of the RyR2 pore plays a pivotal role in the high cation conductance and limited selectivity observed in this channel by introducing into each monomer a double point mutation to neutralize acidic residues in...

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Identifiers

PMID: 19217855
DOI: 10.1016/j.bpj.2008.10.054
PMCID: PMC2717239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19217855-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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