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Article

In vitro modeling of dendritic atrophy in Rett syndrome: determinants for phenotypic drug screening in neurodevelopmental disorders.

Scientific reports - 12 Feb 2020

Nerli Elisa, Roggero Ottavia Maria, Baj Gabriele, Tongiorgi Enrico

Abstract excerpt

Dendritic atrophy, defined as the reduction in complexity of the neuronal arborization, is a hallmark of several neurodevelopmental disorders, including Rett Syndrome (RTT). RTT, affecting 1:10,000 girls worldwide, is mainly caused by mutations in the MECP2 gene and has no cure. We describe here an in vitro model of dendritic atrophy in Mecp2-/y mouse hippocampal primary cultures, suitable for phenotypic...

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Identifiers

PMID: 32051524
DOI: 10.1038/s41598-020-59268-w
PMCID: PMC7016139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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