Article

Loss of MECP2 leads to activation of p53 and neuronal senescence

2017-04-24

Abstract excerpt

To determine the role for mutations of MECP2 in Rett Syndrome, we generated isogenic lines of human iPSCs (hiPSCs), neural progenitor cells (NPCs), and neurons from patient fibroblasts with and without MECP2 expression in an attempt to recapitulate disease phenotypes in vitro . Molecular profiling uncovered neuronal specific gene expression changes including induction of a Senescence Associated Secretory Phenotyp...

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Literature Corpus work: 7529bfd7-8890-5385-b2c4-9feed0e31a06
DOI: 10.1101/130401

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