Article
HIV-1 can persist in aged memory CD4+ T lymphocytes with minimal signs of evolution after 8.3 years of effective highly active antiretroviral therapy.
Journal of acquired immune deficiency syndromes (1999) - 1 Apr 2009
Nottet Hans S L M, van Dijk Sabine J, Fanoy Ewout B, Goedegebuure Irma W, de Jong Dorien, Vrisekoop Nienke, van Baarle Debbie, Boltz Valerie, Palmer Sarah, Borleffs Jan C C, Boucher Charles A B
Abstract excerpt
BACKGROUND: Patients on long-term highly active antiretroviral therapy (HAART) were studied to determine persistence, drug resistance development, and evolution of HIV-1 proviral DNA. METHODS: Peripheral blood mononuclear cells were obtained by large volume blood drawn (500 mL) from 8 clinically successfully treated patients who had received uninterrupted HAART for up to 8.9 years. HIV-1 load was determined by...
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