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Article

DNA instability in replicating Huntington's disease lymphoblasts.

BMC medical genetics - 11 Feb 2009

Cannella Milena, Maglione Vittorio, Martino Tiziana, Ragona Giuseppe, Frati Luigi, Li Guo-Min, Squitieri Ferdinando

Abstract excerpt

BACKGROUND: The expanded CAG repeat in the Huntington's disease (HD) gene may display tissue-specific variability (e.g. triplet mosaicism) in repeat length, the longest mutations involving mitotic (germ and glial cells) and postmitotic (neurons) cells. What contributes to the triplet mutability underlying the development of HD nevertheless remains unknown. We investigated whether, besides the increased DNA...

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Identifiers

PMID: 19210789
DOI: 10.1186/1471-2350-10-11
PMCID: PMC2645380

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