Mitotic stability and meiotic variability of the (CAG)n repeat in the Huntington disease gene.

doi:10.1093/hmg/2.12.2063

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Article

Mitotic stability and meiotic variability of the (CAG)n repeat in the Huntington disease gene.

Human molecular genetics - 1 Dec 1993

Zühlke C, Riess O, Bockel B, Lange H, Thies U

Abstract excerpt

The gene causing Huntington's disease, an autosomal dominantly inherited, neurodegenerative disorder, has been identified recently. The corresponding mutation is involving an expansion in the number of (CAG)n repeats in the coding region of the Huntington's disease gene on chromosome 4. In this r...

Topics

Alleles
Base Sequence
Chromosomes, Human, Pair 4
DNA
DNA Primers
Female
Genes, Dominant
Humans
Huntington Disease
Lymphocytes
Male
Meiosis
Mitosis
Molecular Sequence Data
Mutation
Pedigree
Polymorphism, Genetic
Reference Values

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