Article
Mitotic stability and meiotic variability of the (CAG)n repeat in the Huntington disease gene.
Human molecular genetics - 1 Dec 1993
Zühlke C, Riess O, Bockel B, Lange H, Thies U
Abstract excerpt
The gene causing Huntington's disease, an autosomal dominantly inherited, neurodegenerative disorder, has been identified recently. The corresponding mutation is involving an expansion in the number of (CAG)n repeats in the coding region of the Huntington's disease gene on chromosome 4. In this report, we demonstrate the length variation of the repeat in 513 non-HD chromosomes from normal individuals and HD...
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