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Article

Chemotherapeutic deletion of CTG repeats in lymphoblast cells from DM1 patients.

Nucleic acids research - 1 Jan 2004

Hashem Vera I, Pytlos Malgorzata J, Klysik Elzbieta A, Tsuji Kuniko, Khajavi Mehrdad, Khajav Merhdad, Ashizawa Tetsuo, Sinden Richard R

Abstract excerpt

Myotonic dystrophy type 1 (DM1) is caused by the expansion of a (CTG).(CAG) repeat in the DMPK gene on chromosome 19q13.3. At least 17 neurological diseases have similar genetic mutations, the expansion of DNA repeats. In most of these disorders, the disease severity is related to the length of the repeat expansion, and in DM1 the expanded repeat undergoes further elongation in somatic and germline tissues. At...

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Identifiers

PMID: 15576360
DOI: 10.1093/nar/gkh976
PMCID: PMC535684

Genes

DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Chemotherapeutic deletion of CTG repeats in lymphoblast cells from DM1 patients.PMID 15576360Read ↗

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