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Article

DNA instability in postmitotic neurons

25 Feb 2008

Abstract excerpt

Huntington's disease (HD) is caused by a CAG repeat expansion that is unstable upon germ-line transmission and exhibits mosaicism in somatic tissues. We show that region-specific CAG repeat mosaicism profiles are conserved between several mouse models of HD and therefore develop in a predetermined manner. Furthermore, we demonstrate that these synchronous, radical changes in CAG repeat size occur in terminally...

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PMID: 18299573
DOI: 10.1073/pnas.0800048105

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