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Article

Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain.

Human molecular genetics - 15 May 2007

Shelbourne Peggy F, Keller-McGandy Christine, Bi Wenya Linda, Yoon Song-Ro, Dubeau Louis, Veitch Nicola J, Vonsattel Jean Paul, Wexler Nancy S, Arnheim Norman, Augood Sarah J

Abstract excerpt

Huntington disease is caused by the expansion of a CAG repeat encoding an extended glutamine tract in a protein called huntingtin. Here, we provide evidence supporting the hypothesis that somatic increases of mutation length play a role in the progressive nature and cell-selective aspects of HD pathogenesis. Results from micro-dissected tissue and individual laser-dissected cells obtained from human HD cases and...

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PMID: 17409200
DOI: 10.1093/hmg/ddm054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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