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Article

Inherited CAG.CTG allele length is a major modifier of somatic mutation length variability in Huntington disease.

DNA repair - 1 Jun 2007

Veitch Nicola J, Ennis Margaret, McAbney John P, Shelbourne Peggy F, Monckton Darren G

Abstract excerpt

Huntington disease (HD) is associated with an unstable trinucleotide CAG.CTG repeat expansion. Although the repeat length is inversely correlated with the age-at-onset of symptoms, variability between patients who have inherited the same HD repeat length clearly suggests that other factors influence this aspect of the disease. As repeat length profiles in somatic tissues suggest that repeat length gains may...

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PMID: 17293170
DOI: 10.1016/j.dnarep.2007.01.002

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