Article
A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis.
Human molecular genetics - 1 May 2009
Park Jeong Soon, Sharma Lokendra Kumar, Li Hongzhi, Xiang Ruihua, Holstein Deborah, Wu Jun, Lechleiter James, Naylor Susan L, Deng Janice J, Lu Jianxin, Bai Yidong
Abstract excerpt
Mitochondrial alteration has been long proposed to play a major role in tumorigenesis. Recently, mitochondrial DNA (mtDNA) mutations have been found in a variety of cancer cells. In this study, we examined the contribution of mtDNA mutation and mitochondrial dysfunction in tumorigenesis first usi...
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