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Article

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2009

Brandl Katharina, Rutschmann Sophie, Li Xiaohong, Du Xin, Xiao Nengming, Schnabl Bernd, Brenner David A, Beutler Bruce

Abstract excerpt

Here, we describe an N-ethyl-N-nitrosourea (ENU)-induced missense error in the membrane-bound transcription factor peptidase site 1 (S1P)-encoding gene (Mbtps1) that causes enhanced susceptibility to dextran sodium sulfate (DSS)-induced colitis. S1P cleaves and activates cAMP response element bin...

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Source

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Identifiers

PMID: 19202076
DOI: 10.1073/pnas.0813036106
PMCID: PMC2651297

Genes

ATF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19202076-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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