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Article

Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice.

Cell stress & chaperones - 1 Nov 2010

Christensen Jane H, Nielsen Marit N, Hansen Jakob, Füchtbauer Annette, Füchtbauer Ernst-Martin, West Mark, Corydon Thomas J, Gregersen Niels, Bross Peter

Abstract excerpt

The mitochondrial Hsp60 chaperonin plays an important role in sustaining cellular viability. Its dysfunction is related to inherited forms of the human diseases spastic paraplegia and hypomyelinating leukodystrophy. However, it is unknown whether the requirement for Hsp60 is neuron specific or whether a complete loss of the protein will impair mammalian development and postnatal survival. In this study, we...

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Identifiers

PMID: 20393889
DOI: 10.1007/s12192-010-0194-x
PMCID: PMC3024079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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