Article
Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner.
Cell host & microbe - 17 Mar 2011
Popkin Daniel L, Teijaro John R, Sullivan Brian M, Urata Shuzo, Rutschmann Sophie, de la Torre Juan Carlos, Kunz Stefan, Beutler Bruce, Oldstone Michael
Abstract excerpt
The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), which naturally persists in rodents, represents a model for HIV, HBV, and HCV. Cleavage of the viral glycoprotein precursor by membrane-bound transcription factor peptidase, site 1 (Mbtps1 or site-1 protease), is crucial for the life cycle of arenaviruses and therefore represents a potential target for therapy. Recently, we reported a viable...
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