Article
Polymorphisms in the interleukin-10 and interferon gamma genes in Hodgkin lymphoma.
Leukemia & lymphoma - 1 Dec 2003
Munro L R, Johnston P W, Marshall N A, Canning S J, Hewitt S G, Tveita K, Vickers M A
Abstract excerpt
Genetic factors are known to be important in the development of Hodgkin lymphoma (HL). Interleukin-10 (IL-10) secretion by both malignant and reactive cells is thought to be important in the pathogenesis of HL especially Epstein-Barr virus (EBV) positive cases. Polymorphisms of the IL-10 gene have been reported to be associated with susceptibility to EBV infection. The cytotoxic response to EBV is determined by a...
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