Article
Epstein-Barr virus infection and single nucleotide polymorphisms in the promoter region of interleukin 10 gene in patients with Hodgkin lymphoma.
Archives of pathology & laboratory medicine - 1 Nov 2007
da Silva Glenda Nicioli, Bacchi Maura Moscardi, Rainho Cláudia Aparecida, de Oliveira Deilson Elgui
Abstract excerpt
CONTEXT: Hodgkin lymphoma is a neoplastic disease in which the immune system plays a major role in its pathogenesis. Interleukin 10 (IL-10), an immunosuppressive cytokine actively produced in patients with Hodgkin lymphomas, favors the survival of the Hodgkin/Reed-Sternberg cells. Individual variations in IL-10 levels may be due, in part, to the presence of single nucleotide polymorphisms in the IL10 gene...
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