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Article

Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2008

Kube Dieter, Hua Thanh-Duc, von Bonin Frederike, Schoof Nils, Zeynalova Samira, Klöss Marita, Gocht Daniela, Potthoff Bernd, Tzvetkov Mladen, Brockmöller Jürgen, Löffler Markus, Pfreundschuh Michael, Trümper Lorenz

Abstract excerpt

PURPOSE: Current chemotherapy can achieve high response rates in aggressive non-Hodgkin's lymphoma (NHL), but the factors that influence regression and survival remain unknown. The present exploratory study tested the hypothesis whether interleukin-10 (IL-10) polymorphisms predict clinical outcome, leukocytopenia, or infectivity during therapy. IL-10 was chosen because immune alterations are a major risk factor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18559596
DOI: 10.1158/1078-0432.CCR-07-5182

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