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Article

Characterization of the Interaction of Lassa Fever Virus with Its Cellular Receptor α-Dystroglycan

27 Apr 2005

Abstract excerpt

The cellular receptor for the Old World arenaviruses Lassa fever virus (LFV) and lymphocytic choriomeningitis virus (LCMV) has recently been identified as alpha-dystroglycan (alpha-DG), a cell surface receptor that provides a molecular link between the extracellular matrix and the actin-based cytoskeleton. In the present study, we show that LFV binds to alpha-DG with high affinity in the low-nanomolar range....

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PMID: 15857984
DOI: 10.1128/jvi.79.10.5979-5987.2005

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