Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.

doi:10.1038/ng.314

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Article

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.

Nature genetics - 1 Mar 2009

Trégouët David-Alexandre, König Inke R, Erdmann Jeanette, Munteanu Alexandru, Braund Peter S, Hall Alistair S, Grosshennig Anika, Linsel-Nitschke Patrick, Perret Claire, DeSuremain Maylis, Meitinger Thomas, Wright Ben J, Preuss Michael, Balmforth Anthony J, Ball Stephen G, Meisinger Christa, Germain Cécile, Evans Alun, Arveiler Dominique, Luc Gérald, Ruidavets Jean-Bernard, Morrison Caroline, van der Harst Pim, Schreiber Stefan, Neureuther Katharina, Schäfer Arne, Bugert Peter, El Mokhtari Nour E, Schrezenmeir Jürgen, Stark Klaus, Rubin Diana, Wichmann H-Erich, Hengstenberg Christian, Ouwehand Willem, Ziegler Andreas, Tiret Laurence, Thompson John R, Cambien Francois, Schunkert Heribert, Samani Nilesh J

Abstract excerpt

We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

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PMID: 19198611
DOI: 10.1038/ng.314

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