Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold.

Mechanisms of ageing and development - 1 Mar 2009

Yen Kelvin, Patel Harshil B, Lublin Alex L, Mobbs Charles V

Abstract excerpt

The free radical theory of aging is one of the most prominent theories of aging and senescence, but has yet to be definitively proven. If free radicals are the cause of senescence, then the cellular anti-oxidant system should play a large role in lifespan determination. Because superoxide dismutase (SOD) plays a central role in detoxifying superoxide radicals, we have examined the effects of mutational...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Caloric Restriction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Cold Temperature

Share to Longevity

Share to Paraquat

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Identifiers

PMID: 19059428
DOI: 10.1016/j.mad.2008.11.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold.PMID 19059428Read ↗

A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.Semantic proximity Read ↗

Superoxide dismutase is dispensable for normal animal lifespan.Semantic proximity Read ↗

Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span.Semantic proximity Read ↗

Long-lived worms and aging.Semantic proximity Read ↗

Mitochondrial superoxide acts in the intestine to extend longevitySemantic proximity Read ↗

Redox regulation, gene expression and longevity.Semantic proximity Read ↗

Mitochondrial changes in ageing Caenorhabditis elegans--what do we learn from superoxide dismutase knockouts?Semantic proximity Read ↗

Modulation of longevity and diapause by redox regulation mechanisms under the insulin-like signaling control in Caenorhabditis elegans.Semantic proximity Read ↗

Effects of the mitochondrial respiratory chain on longevity in C. elegans.Semantic proximity Read ↗

Effects of sod gene overexpression and deletion mutation on the expression profiles of reporter genes of major detoxification pathways in Caenorhabditis elegans.Semantic proximity Read ↗

Mechanisms of aging: an appraisal of the oxidative stress hypothesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.