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Article

Tdp1 protects against oxidative DNA damage in non-dividing fission yeast.

The EMBO journal - 18 Mar 2009

Ben Hassine Samia, Arcangioli Benoit

Abstract excerpt

In humans, a mutation in the tyrosyl-DNA phosphodiesterase (Tdp1) is responsible for the recessively inherited syndrome spinocerebellar ataxia with axonal neuropathy (SCAN1). Tdp1 is a well-conserved DNA repair enzyme, which processes modified 3' phospho-DNA adducts in vitro. Here, we report that in the yeast Schizosaccharomyces pombe, tdp1 mutant cells progressively accumulate DNA damage and rapidly lose...

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Source

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Identifiers

PMID: 19197239
DOI: 10.1038/emboj.2009.9
PMCID: PMC2666031

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tdp1 protects against oxidative DNA damage in non-dividing fission yeast.PMID 19197239Read ↗

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