Article
Knockin of mutant PIK3CA activates multiple oncogenic pathways.
Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2009
Gustin John P, Karakas Bedri, Weiss Michele B, Abukhdeir Abde M, Lauring Josh, Garay Joseph P, Cosgrove David, Tamaki Akina, Konishi Hiroyuki, Konishi Yuko, Mohseni Morassa, Wang Grace, Rosen D Marc, Denmeade Samuel R, Higgins Michaela J, Vitolo Michele I, Bachman Kurtis E, Park Ben Ho
Abstract excerpt
The phosphatidylinositol 3-kinase subunit PIK3CA is frequently mutated in human cancers. Here we used gene targeting to "knock in" PIK3CA mutations into human breast epithelial cells to identify new therapeutic targets associated with oncogenic PIK3CA. Mutant PIK3CA knockin cells were capable of epidermal growth factor and mTOR-independent cell proliferation that was associated with AKT, ERK, and GSK3beta...
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