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Article

Induction of Neuronal Cell Death by Rab5A-dependent Endocytosis of α-Synuclein

1 Jul 2001

Abstract excerpt

The presynaptic alpha-synuclein is a prime suspect for contributing to Lewy pathology and clinical aspects of diseases, including Parkinson's disease, dementia with Lewy bodies, and a Lewy body variant of Alzheimer's disease. Here we examined the pathogenic mechanism of neuronal cell death induced by alpha-synuclein. The exogenous addition of alpha-synuclein caused a marked decrease of cell viability in primary...

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PMID: 11316809
DOI: 10.1074/jbc.m101318200

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