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Article

Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease.

Journal of Parkinson's disease - 1 Jan 2011

Coune P G, Bensadoun J C, Aebischer P, Schneider B L

Abstract excerpt

Although the overabundance of human alpha-synuclein in nigral dopaminergic neurons is considered to play a pathogenic role in Parkinson's disease (PD), it remains unclear how alpha-synuclein leads to neuronal degeneration and motor symptoms. Here, we explored the effect of human alpha-synuclein in the rat substantia nigra following AAV-mediated gene delivery inducing a moderate loss of dopaminergic neurons...

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Identifiers

PMID: 23939344
DOI: 10.3233/JPD-2011-11058

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