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Article

Molecular Characterization and Clinical Impact of<i>TMPRSS2-ERG</i>Rearrangement on Prostate Cancer: Comparison between FISH and RT-PCR

1 Jan 2013

Abstract excerpt

Prostate cancer (PCa) is a very heterogeneous disease, and there are constraints in its current diagnosis. Serum PSA levels, digital rectal examination (DRE), and histopathologic analysis often drive to overdiagnosis and overtreatment. Since 2005, the presence of the genetic rearrangement between transmembrane-serine protease gene (TMPRSS2) and the erythroblast transformation-specific (ETS) member ERG (v-ets...

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PMID: 23781502
DOI: 10.1155/2013/465179

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