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Article

Recurrent Fusion of <i>TMPRSS2</i> and ETS Transcription Factor Genes in Prostate Cancer

27 Oct 2005

Abstract excerpt

Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We used a bioinformatics approach to discover candidate oncogenic chromosomal aberrations on the basis of outlier gene expression. Two ETS transcription factors, ERG and ETV1, were identified as outliers in prostate cancer. We identified recurrent gene fusions of the 5' untranslated region of TMPRSS2 to ERG or ETV1 in...

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PMID: 16254181
DOI: 10.1126/science.1117679

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Recurrent Fusion of <i>TMPRSS2</i> and ETS Transcription Factor Genes in Prostate CancerPMID 16254181Read ↗

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[TMPRSS2-ETS gene fusion in prostate cancer].Semantic proximity Read ↗

ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor.Semantic proximity Read ↗

Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumorsSemantic proximity Read ↗

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ETS fusion genes in prostate cancerSemantic proximity Read ↗

<i>TMPRSS2:ERG</i> Fusion by Translocation or Interstitial Deletion Is Highly Relevant in Androgen-Dependent Prostate Cancer, But Is Bypassed in Late-Stage Androgen Receptor–Negative Prostate CancerSemantic proximity Read ↗

ETS Gene Fusions in Prostate Cancer: From Discovery to Daily Clinical PracticeSemantic proximity Read ↗

TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer.Semantic proximity Read ↗

Multiple genomic alterations on 21q22 predict various <i>TMPRSS2/ERG</i> fusion transcripts in human prostate cancersSemantic proximity Read ↗

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