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Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study

21 Aug 2008

Abstract excerpt

We have identified an alternative pathway of tumorigenesis in sporadic colon cancer, involving microsatellite instability due to mismatched repair methylation, which may be driven by mutations in the BRAF gene (V600E). Colorectal cancer (CRC) is the most common cancer in the world, and African Americans show a higher incidence than other populations in the United States. We analyzed sporadic CRCs in Omani (of...

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PMID: 18718023
DOI: 10.1186/1476-4598-7-68

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