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Article

Mutational analysis of the BRAF, RAS and EGFR genes in human adrenocortical carcinomas.

Endocrine-related cancer - 1 Jun 2009

Kotoula Vassiliki, Sozopoulos Elias, Litsiou Helen, Fanourakis Galinos, Koletsa Triantafyllia, Voutsinas Gerassimos, Tseleni-Balafouta Sophia, Mitsiades Constantine S, Wellmann Axel, Mitsiades Nicholas

Abstract excerpt

The serine/threonine kinase B-Raf plays a key role in the Ras/Raf/MEK/ERK pathway that relays extracellular signals for cell proliferation and survival. Several types of human malignancies harbor activating BRAF mutations, most frequently a V600E substitution. The epidermal growth factor receptor...

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Source

Identifiers

PMID: 19190079
DOI: 10.1677/ERC-08-0101

Genes

EGFR
BRAF
KRAS
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19190079-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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