An antagonistic vascular endothelial growth factor (VEGF) variant inhibits VEGF-stimulated receptor autophosphorylation and proliferation of human endothelial cells.

doi:10.1073/pnas.95.8.4625

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Article

An antagonistic vascular endothelial growth factor (VEGF) variant inhibits VEGF-stimulated receptor autophosphorylation and proliferation of human endothelial cells.

Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 1998

Siemeister G, Schirner M, Reusch P, Barleon B, Marmé D, Martiny-Baron G

Abstract excerpt

Vascular endothelial growth factor (VEGF) is a potent mitogen with a unique specificity for endothelial cells and a key mediator of aberrant endothelial cell proliferation and vascular permeability in a variety of human pathological situations, such as tumor angiogenesis, diabetic retinopathy, rh...

Topics

Binding Sites
Binding, Competitive
Cell Division
Cells, Cultured
Cloning, Molecular
Dimerization
Endothelial Growth Factors
Endothelium, Vascular
Genetic Variation
Humans
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphokines

Models, Molecular

Mutagenesis, Site-Directed

Phosphorylation

Receptor Protein-Tyrosine Kinases

Receptors, Growth Factor

Receptors, Vascular Endothelial Growth Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 9539788
DOI: 10.1073/pnas.95.8.4625
PMCID: PMC22540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9539788-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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