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Article

An antagonistic vascular endothelial growth factor (VEGF) variant inhibits VEGF-stimulated receptor autophosphorylation and proliferation of human endothelial cells.

Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 1998

Siemeister G, Schirner M, Reusch P, Barleon B, Marmé D, Martiny-Baron G

Abstract excerpt

Vascular endothelial growth factor (VEGF) is a potent mitogen with a unique specificity for endothelial cells and a key mediator of aberrant endothelial cell proliferation and vascular permeability in a variety of human pathological situations, such as tumor angiogenesis, diabetic retinopathy, rheumatoid arthritis, or psoriasis. VEGF is a symmetric homodimeric molecule with two receptor binding interfaces lying...

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Identifiers

PMID: 9539788
DOI: 10.1073/pnas.95.8.4625
PMCID: PMC22540

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